There are studies on the effect of psychedelic drugs on PTSD, depression, anxiety, etc. It’s possible he suffered from an undiagnosed mental illness and somehow this one time dose “cured” him? Also, just there are other similar studies on personality changes after one-time drug use.
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Researchers found that individuals who took even a single dose of psychedelic drugs like LSD, “magic” mushrooms, and ayahuasca could experience sustained personality changes that lasted several weeks, months, or even years — but oftentimes, these changes were for the better.