First off, you absolutely shouldn’t worry that the drugs did any damage to your husband’s brain or health. Using mushrooms once is very unlikely to have negative health impacts, and any problems that did come up are the sort that would have happened on the day he took them (gastro-intestinal issues, a traumatic “bad trip.
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Psychedelics are used in therapeutic settings by legitimate medical professionals, and your husband had basically the ideal outcome: he took them once and it changed his perspective in a way that let him start making healthier choices.
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